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[2] This is the closest the field has come to direct human validation, and the results are encouraging without being definitive

This is mainly reflected in the more prominent therapeutic advantages of HUC-MSCs in PAH, including improving right ventricular function, inhibiting pulmonary vascular remodeling, enhancing pulmonary colonization, regulating immuno-inflammatory responses, and repairing relevant signaling pathways (Lee et al., 2015