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In models of cerebral ischemia (stroke), it has protected brain tissue from damage and improved functional recovery by reducing inflammation and apoptosis in the ischemic penumbra (Raghavan and Shah 2015)
SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
Obesity drugs that demonstrate benefits in cardiovascular disease, chronic kidney disease, sleep apnea, MASH, and metabolic syndrome may command stronger payer support and longer treatment duration
Understanding tirzepatide Tirzepatide, known by the brand names Mounjaro and Zepbound, is a groundbreaking medication for the management of type 2 diabetes and weight loss
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