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Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy
Sirtuins, including SIRT3, play a central role by deacetylating key proteins in the electron transport chain, cyclophilin D of the mitochondrial permeability transition pore (MPTP), and antioxidant enzymes such as superoxide dismutase 2 (SOD2) [36, 37]
Chronic elevated cortisol promotes abdominal fat storage and interferes with sleep (which further promotes weight gain)
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