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As Met reduces the synthesis of TNF-, it may trigger an autoregulatory mechanism that influences the CX3CR1 expression (Matsumiya et al

Severe appetite suppression to the point of food aversion (not just reduced hunger)

Because persistent adipose tissue inflammation and fibrosis are major risk factors for post-weight loss metabolic deterioration, future studies should investigate whether prolonged Tir treatment or combination approaches targeting macrophage activation and fibrotic remodeling can achieve more complete adipose tissue restoration and durable metabolic recovery

A washout period may sometimes be recommended, though not always required, depending on the last dose taken and the reason for switching