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Weight loss tends to lower blood pressure long-term, so its not a major issue, but if you already have high blood pressure, keep an eye on it

doi: 10.1016/j.exger.2015.07.014 125 FengLLiBXiYCaiMTianZ

Am I comfortable giving myself an injection on a regular basis

Yes, according to UK prescribing guidance, if Wegovy has been discontinued for more than two consecutive doses, treatment should generally be reinitiated at 0.25 mg once weekly and gradually re-titrated to minimise gastrointestinal side effects and ensure safety