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The potencies observed in cellular assays show that it is a potent agonist at the GIP receptor, but exhibits balanced activity across GLP-1 and Glucagon receptors
Since Retatrutide itself requires only weekly injection, adding TB-500 minimally increases injection frequency while significantly expanding the support provided to the body
In addition, solvent use was minimized and reaction time only slightly increased (this 29-mer peptide was synthesised at 15 mmol scale in only 15 hours)
doi: 10.1001/jama.2021.1831 20 WildingJPHBatterhamRLCalannaSDaviesMVan GaalLFLingvayIet al
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