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Effectiveness Comparison When it comes to semaglutide vs tirzepatide effectiveness, the clinical trial results are staggering: Semaglutide Results Average weight loss: 15-17% of body weight 83% of patients lost at least 5% of their weight 66% lost at least 10% of their weight 48% achieved 15% or greater weight loss Tirzepatide Results Average weight loss: 16-22% of body weight 91% of patients lost at least 5% of their weight 83% lost at least 10% of their weight 57% achieved 20% or greater weight loss To put this in perspective, if you weigh 200 pounds, semaglutide could help you lose 30-34 pounds on average, while tirzepatide could help you lose 32-44 pounds

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