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Biological activity of the endocannabinoid system Once in the body, 9 -THC and CBD exert their effects via the endocannabinoid system (ECS).The identification of the specific binding sites for 9 -THC in the brain [45], complemented by the cloning of the cannabinoid receptor 1 (CB1), that led to the development of the concept of a cannabinoid receptor system given the binding of 9 -THC to CB1 as a partial agonist [46]
Acid Reflux and Heartburn Heartburn, or gastroesophageal reflux disease (GERD), is another side effect that can be intensified by coffee
Studies have confirmed that phloretin has a protective effect on hepatotoxicity and endothelial dysfunction induced by a high choline diet in mice (91)
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