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Interestingly, another study showed that NRF2 overexpression increased human telomerase reverse transcriptase (hTERT) levels and upregulated the expression of two PPP enzymes, G6PD and TKT, which could promote the progression of glioblastoma [100]
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Significantly, about 60 percent of new drug approvals in the US and over 65 percent in Europe now involve CDMO support
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