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It depends on how bad the deficiency is and how well the person responds to treatment
Heart failure was not clearly defined in trials protocols, left ventricular ejection fraction was reported only in EXSCEL trial and in 4 trials heart failure functional class was defined
As the advantages of exendin-4 in vivo were detectable acutely, in a dose-dependent manner, it is likely that they are partly attributable to agonist potency differences rather than the post-endocytic trafficking phenotypes
CJC-1295 is a potent GHRH analogue known for its extended half-life, allowing sustained GH release in experimental models
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