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In vitro studies have characterised its binding interactions with nitric oxide-related signalling systems and effects on extracellular matrix protein expression in cell culture models
[60] Nintedanib [edit] Nintedanib is a triple angiokinase inhibitor that targets receptor tyrosine kinases involved in the regulation of angiogenesis: fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR), [61] which have also been implicated in the pathogenesis of fibrosis and IPF
Rajib: Gut
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