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Seek medical attention if you experience extreme thirst with massive urine output (possible diabetic emergency), dark urine despite adequate fluid intake, pain or burning during urination, blood in urine, sudden decrease in urine output, or if increased urination persists beyond 12 weeks without improvement

And now new research, reported in the UK media, suggests that the other health gains are reversed too

However, mTORC2 is more resistant to the effect of rapamycin which needs long-term duration to be inhibited (Chong et al

Research shows it may be effective for several chronic diseases, including diabetes, cardiovascular disorders and inflammatory diseases