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Children with rare mutations in the CBS or MTR genes can have neural tube defects, early atherosclerosis, or neurological effects.[ref] Related article : MTHFR and the methylation cycle Sex, age, and smoking: Men tend to have higher homocysteine levels than women, and homocysteine levels in both sexes tend to increase slightly with age

Chem Biol Interact 340:109447 Hussein AM, Eldosoky M, El-Shafey M et al (2019) Effects of metformin on apoptosis and -synuclein in a rat model of pentylenetetrazole-induced epilepsy [J]