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Detailed Category Analysis# Receptor Targets# Retatrutide : Triple agonist: GIP, GLP-1, and glucagon receptors simultaneously Tirzepatide : Dual agonist: GIP and GLP-1 receptors Advantage : Retatrutide Weight Loss Efficacy# Retatrutide : Up to 28.7% body weight reduction at 68 weeks (Phase 3 TRIUMPH-4)
How Compounded GLP-1 Alternatives Can Increase the Risk of Side Effects Side effects are a risk with any Ozempic or Wegovy prescription, but they are particularly concerning for patients who are getting off-brand compounded versions of semaglutides
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MC1R Activation (Pigmentation): Binds to receptors on melanocytes, increasing intracellular cAMP
