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Excessive cytokine activity, including IL-1, IL-6, and TNF-, amplifies these alterations (Hughes et al
7 To emphasize this approach to care, the 2020 Standards include a decision cycle for patient-centered glycemic management in type 2 diabetes . The ADA recommends that the decision cycle be undertaken at least once or twice annually to reevaluate patient needs and avoid clinical inertia such that patient-specific treatment goals can be achieved
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