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This work therefore adds an additional layer of regulation for GLP-1/Notch activity, namely that the interaction between a Delta-like membrane-bound ligand and the Notch receptor at the surface of stem cells within an adjacent tissue is favoured by increasing levels of COL IV, and thus most likely the stiffness, of the surrounding basement membrane 34

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Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy