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According to the MHRA/EMC SmPC for Wegovy, the most frequently reported gastrointestinal side effects include: Nausea the most common adverse effect, affecting approximately 44% of patients in clinical trials, typically most pronounced during dose escalation Diarrhoea reported in around 30% of patients, ranging from mild to moderate severity Constipation affecting approximately 24% of patients, related to slowed gut transit Vomiting occurring in roughly 24% of patients, often associated with nausea Abdominal pain or discomfort reported by approximately 20% of patients Dyspepsia (indigestion) affecting around 9% of patients Bloating and flatulence commonly reported but less precisely quantified in trials These side effects are dose-dependent , meaning they tend to be more pronounced at higher doses and during the escalation phase

Patients with MEN 2 syndrome warrant particular attention, as this hereditary condition predisposes to MTC, pheochromocytoma, and parathyroid adenomas

(2) M2 microglia regulated immunity and the balance between oligodendrogenesis and neurogenesis by secreting IL-4 and IL-10 (83, 84)

It is intended for use in reconstituting or diluting medications prior to injection