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Tumor cells form a two-way connection with circumferent stroma in the early stage of invasion and after that, tumor-stroma interaction helps the tumor to develop toward metastasis ( Pre-Metastatic Niche An appropriate microenvironment, namely, pre-metastatic niche, can be established in secondary tissues and organs before metastases occurring through a complicated mechanism by interaction between the primary tumors and organs stromal components ( via the VEGFR-1/Flt-1 pathway, which is important for lung metastasis ( Organotropism The site-specific metastasis of breast cancer is related to subtypes and divergent gene signatures of metastatic cancer cells
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Conclusion Remarkably, the locally isolated T
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