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Materials needed Your Melanotan I vial (lyophilized) Alcohol swabs Bacteriostatic sterile water 3 mL syringes (Luer Lock tip) 25G or 27G needles (Luer Lock)

MCE, HY-100579), RSL3 (MCE, HY-10018A) and MK-571 (MCE, HY-19989) were diluted in dimethyl sulfoxide (DMSO

Halo Nevus This is a light ring or halo around a mole

After heating one (A 1 ) to 100C for 15 h in a sealed vial, 1 ml of buffer solution containing 208 mm-sodium hydroxide, 127 mm-sodium tetraborate and a surfactant was added to all samples (A 1 and B 1 )