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For example, in the case of amylin biology, significant translational gaps between rodent and human systems persist, the optimal receptor selectivity profile for clinical use remains unclear, and molecules continue to advance in clinical development despite these uncertainties (Hollander et al., 2020)
The role of neuroinflammation in depression is well-established, with elevated levels of pro-inflammatory cytokines and reduced levels of anti-inflammatory cytokines being associated with depressive symptoms 20
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