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Individuals with a homozygous A allele of the CYP1A2 gene tend to produce more cytochrome P450, an enzyme responsible for about 95% of caffeine metabolism, and consequently metabolize CAF more quickly
Preoperative planning requires particular attention: according to 2024 multi-society guidance (including the American Society of Anesthesiologists), most patients can continue GLP-1 receptor agonists perioperatively
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