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The analogous assay was performed to analyze the impact of exchanging the structurally-determined BRD4 BD2 region with the corresponding YPEL5/degrader-contacting loop of BRD4 BD1 on engaging the parental JQ1 inhibitor (Extended Data Fig

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Incomplete FAO leads to the accumulation of even-chain acylcarnitines from C4 to C22 in the mitochondria, with a corresponding decrease in carnitine levels [6]