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14 Use of metformin for weight reduction in these populations may result in favorable long-term outcomes in preventing complications of obesity such as T2D, cardiovascular disease, and other obesity-related comorbid conditions

Although the increased susceptibility to prostatitis caused by low testosterone and peripheral hormonal changes driven by metabolic syndrome are non-negligible confounding factors, translational medical research has confirmed, after excluding these systemic backgrounds, that the concentration of 17-estradiol (E2) in the seminal plasma of CP patients is significantly higher than that of healthy controls, whereas peripheral plasma E2 levels show no such variation

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Monitoring: The process is supervised to ensure comfort and safety