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Further, 12 of them have been recognized as putative drug transporters, including well-known P-gp encoded by the ABCB1 gene, MDR-associated protein 1 (MRP1, encoded by the ABCC1 gene), and ABC subfamily G member2, also known as breast cancer resistance protein, which is encoded by the ABCG2 gene [78, 79]
If a patient, after consulting with a prescriber, has a specific medical need that cannot be met with an FDA-approved medication, then patients can be prescribed patient-specific compounded medications that may include, if appropriate, two or more active ingredients that would be impractical or impossible to administer with two separate prescription orders for each medication to fit the patients unique needs
third, combination therapy may work differently in different phenotypes of type 2 diabetes[17]
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