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High-concentration patches, available by prescription, are applied in a medical office and can provide relief for up to three months
Simultaneously, the peptide is proposed to inhibit lipogenesisthe de novo synthesis of triglycerides from acetyl-CoA and glycerolby suppressing fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) activity
Furthermore, statins improve mitochondrial function by increasing levels of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1), thus enhancing energy production and cardiomyocyte survival (Wang and Wong 2010)
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