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However, it is known that through dietary intake and/or supplementation, antioxidants such as vitamin C, E, and carotenoids are deposited into the epidermis at higher concentrations compared with the dermis [4,5,6], which suggests the importance of inside to outside treatment of the skin

Both approaches aim to promote tissue repair and regeneration, though through different biological mechanisms and pathways

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Realistic expectation: Users running microneedling plus GHK-Cu often see at week 8 what topical-only users see at week 12