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At a dose of 10 nmol kg 1 GLP-1RA/tesaglitazar showed slightly superior efficacy at improving glucose control (Fig

Cardiovascular and Metabolic Risk Factors That Matter Patients with a history of hypertension, coronary artery disease, arrhythmia, or family history of sudden cardiac death should not combine these agents without exhaustive cardiac evaluation

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Additionally, in a post-hoc analysis of the SURPASS-4 trials, tirzepatide showed a slower rate of eGFR decline and lower urinary albumin creatinine values as compared to patients who were treated with glargine insulin [75, 76]