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The mean change in body weight from baseline to week 104 was -15.2% in the semaglutide group (n = 152) versus -2.6% with placebo (n = 152), for an estimated treatment difference of -12.6 %-points (95% confidence interval, -15.3 to -9.8

When you stop the medication, you will get your appetite back, so you will not feel full for as long after a meal

While it wasnt blocking the opening to the small intestine, it was taking up a lot of space and making it harder for food to pass through

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