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Meanwhile, dual agonists, which target and activate both the GLP-1 (Glucagon-like peptide-1) receptor and the GIP (glucose-dependent insulinotropic polypeptide) receptor, and triple agonists (targeting the GLP-1+GIP+Glucagon receptors) are also showing promise
However, studies in mice show NR is more effectively taken up than NMN in some tissues, such as skeletal muscle 39 , highlighting the importance of the choice of precursor treatment depending on the intended target organ
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