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There are several incretin hormones, but GLP-1 appears to be the major player in type 2 diabetes and is best understood
10 , 11 Recently, the investigation of liraglutide plus sitagliptin demonstrated intensified GLP-1 levels without any increase in C-peptide and insulin
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Emerging agents like Tirzepatide, which activates both GLP-1 and GIP receptors, and Orforglipron, a nonpeptide oral GLP-1 agonist in phase 2 trials, further expand the therapeutic potential of this class (23)(24)
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