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p53 was activated in DKD and induced the expression of miR-214, which targeted ULK1 and hindered the initiation of autophagy, leading to impaired autophagy in PTEC
Ozone can also react directly with tertiary amines, leading to the formation of amine oxides or to dealkylation products such as secondary amines and aldehydes
Gut 65, 426436
This MC1R selectivity makes it a more targeted research tool for melanocyte biology studies, though it retains measurable activity at other melanocortin receptor subtypes in binding assays
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