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In Fxr/Shp double-knockout mice, BA accumulation inhibits Pgc1 transcriptional activity and downregulates core fatty acid oxidation genes (e.g., Cpt1b, Acadl), thereby reducing mitochondrial -oxidation rates
Oral supplements can help maintain levels over time, while IV therapy provides a direct boost for individuals with higher oxidative stress
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Designed to reduce appetite, decrease energy intake, and increase satiety, CagriSema has shown promising results in both weight management and type 2 diabetes
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