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First, 72 percent of participants who entered the trial with prediabetes reverted to normoglycemia by week 68

Increased Energy Expenditure: GLP-1 RAs may activate sympathetic pathways in the hypothalamus (specifically the dorsomedial and ventromedial nuclei) that increase thermogenic activity in brown adipose tissue (BAT), contributing to increased energy expenditure and weight loss

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The injections support hepatic fat metabolism but do not independently cause fat loss outcomes depend entirely on adherence to dietary restriction and exercise