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We used an mGIPR-Ab that fully neutralizes GIPR activity in vitro and prevents body weight gain in obese mice when dosed systemically 17
However, bioavailability could not be reliably estimated since the chosen dose level for intravenous administration was too low for the terminal part of the concentration-time curve to be apparent, and the plasma semaglutide exposure levels in this single-dose trial were generally insufficient for a robust estimation of bioavailability
The GLP-1 revolution has fundamentally altered public perception of peptide-based medicine
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