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doi: 10.1002/mco2.693 27 MaserRSDePinhoRA

Therapeutic strategies aiming at iron metabolism as a possible target in MDS and AML can be roughly distributed in four approaches: reduction of iron required for cellular functions via iron chelation, modulation of proteins involved in iron metabolism, induction of ferroptosis und exploitation of iron proteins for the delivery of antileukemic drugs ( Figure 3 )

Stromal DHAR was thought to be superfluous, given the fast chemical reduction of dehydroascorbate (DHA) by reduced glutathione (GSH), particularly at alkaline pH (Foyer and Halliwell 1976, 1977)

It contains BPC-157 (5mg), a 15-amino-acid synthetic peptide derived from a partial sequence of human gastric juice protein