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International journal of molecular sciences, 24(23), 16588
Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues
By leveraging patent thickets aimed at extending the market monopolies on their blockbuster drugs, these companies seek to maximize revenue streams while delaying the entry of low-cost generic alternatives
As shown in Table 1, grains and vegetables contain only small to modest amounts of ergothioneine
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