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High doses of B12, often used to treat deficiencies, may cause side effects such as headaches, nausea, diarrhea, fatigue or weakness, and tingling in the hands and feet
"Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers"
High-dose niacin therapy is normally contraindicated in individuals with active peptic ulcer disease or active liver disease
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