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It lowers blood sugar and hemoglobin A1C levels and reduces the risk of major cardiovascular events in type 2 diabetes patients
Key findings include: Treatment duration: 72 weeks Average weight loss: Approximately 20.7% of starting weight High responders: Around one-third of participants achieved 25% or greater weight reduction Comparison to standard dose: Substantially better results than the standard 2.4mg dose, which achieved 17-17.5% in earlier semaglutide trials This represents a meaningful step up from what patients could achieve on the lower maintenance dose, closing much of the gap with Mounjaros performance in large clinical trials
Nature 444 , 840846 (2006)
The team then showed that mice whose gut microbiota had been depleted using broad-spectrum antibiotics did not experience liraglutides antidepressant effects, pointing to a key role for the microorganisms in the gut
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