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The results showed that LC significantly increased the expression of CYP11A1(cytochrome p450 11A1) (related to steroidogenesis) and TXNIP (thioredoxin interacting protein) (related to oxidative stress) and increased serum levels of follicle-stimulating hormone (FSH), reduced testosterone, luteinizing hormone (LH), glucose, insulin, and homeostasis model assessmentinsulin resistance
2025 Jul;27(7):3607-3626
This protective mechanism, while crucial for brain health, presents a significant challenge for drug delivery, hindering the development of therapies that target central GLP-1 pathways
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