We have a member of our family, who suffers from hypothyroidism, had BMI=37, underwent bariatric surgery and shed off ~40 kg from 125 kg in 3 years
Update (2026): This 2018 note covers LY3298176 (tirzepatide) at an early phase
Sustained hyperglycemia induces early retinal neurodegeneration, manifested as the loss of retinal ganglion cells, photoreceptors, and other neuronal populations (42), through mechanisms including oxidative stress, chronic low-grade inflammation, glutamate-mediated excitotoxicity, and mitochondrial dysfunction, all of which converge to promote neuronal apoptosis (89, 90)
Your body's tolerance improves as GLP-1 signaling normalizes in the hypothalamus and gastrointestinal tract