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Beyond scavenging free radicals and protecting cells from oxidative damage, glutathione supports crucial physiological functions such as immune system modulation, detoxification of harmful substances, and even influencing gene expression related to cell proliferation and apoptosis
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Further mechanistic studies revealed that the synergistic effect was mediated by the down-regulation of ERBB2 and BIRC5 and the up-regulation of Caspase-3 expression (69)
Intracellular antioxidant system of melanocytes Due to the high risk of melanocytes exposure to harmful and prooxidant factors of the external environment, these cells are characterized by naturally well-developed complex antioxidant systems, including enzymatic and non-enzymatic antioxidants (Fig
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