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The patient ends up in a worse body composition position than before treatment began
Temporary nausea, constipation, or mild digestive issues are common early on but usually improve with time
This is important to prevent waste product build-up and intracellular toxicity
For this reason, propagated cell death should ideally be supported by multiple orthogonal criteria, including iron dependence, rescue by structurally distinct ferroptosis inhibitors, and preservation of canonical molecular hallmarks of ferroptosis
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