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GLP-1 activation primarily causes nausea and appetite suppression, while GIP signaling contributes to energy metabolism changes
Important note for oral semaglutide (Rybelsus): According to the SmPC, this medication must be taken on an empty stomach with a small sip of water (up to 120 ml), and patients must wait at least 30 minutes before consuming any food, drink, or other oral medications, including supplements
Knowing how long semaglutide takes to work helps set expectations for when these initial adjustments resolve
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