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Schedule prompt medical evaluation (within 24-48 hours) for: Gradually worsening shortness of breath over days to weeks Dyspnea with exertion that is new or significantly worse than baseline Breathing difficulty accompanied by persistent cough or fever Leg swelling, weight gain, or orthopnea (difficulty breathing when lying flat) Respiratory symptoms associated with severe ongoing nausea, vomiting, or inability to maintain hydration Patients should not discontinue GLP-1 medications without medical guidance (except in cases of suspected severe allergic reactions), but should contact their healthcare provider promptly to discuss respiratory symptoms

FDA Maps Generic Path for Semaglutide, Tirzepatide The FDA published 17 revised generic-peptide guidances and pulled its 2021 synthetic-peptide rule

These effects often relate to slowed gastric emptying and can be managed with smaller bites, slower eating, reduced fat intake during titration, and adequate hydration

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