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The effect is dose-responsive: more activity confers more benefit, but the greatest gains occur when someone moves from being inactive to moderately active. Underlying health conditions can also contribute, adds Kubala
Incretin Pathways Influencing Reward Circuits Incretin-based medications such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, including tirzepatide, have become important treatments for obesity and diabetes
For glucose control, GLP-1 medications are often comparable to basal insulin, though high-dose insulin remains more potent for severe hyperglycemia
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