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While adult studies have shown that Metformin can help prevent the progression to T2D (186188), most pediatric studies have focused on markers of insulin sensitivity rather than T2D development as an outcome

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Moreover, lipid peroxidation disrupts the acrosomal membrane, diminishing the sperms capacity to fuse with the oocyte

Both semaglutide and liraglutide are MHRA-approved and are supported by NICE technology appraisals TA875 for semaglutide and TA664 for liraglutide which set out specific eligibility criteria