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Dubchenko E, Ivanov A, Spirina N, Smirnova N, Melnikov M, Boyko A, Gusev E, Kubatiev A (2020) Hyperhomocysteinemia and endothelial dysfunction in multiple sclerosis
No changes in cancer markers, hormones, liver, or kidney function reported (only monitored in the short term days)
Phase 3 trials of CagriSema demonstrated: 15.6% body weight loss with the combination versus 8.1% with semaglutide alone Superior glycemic control compared to either component individually Manageable side effect profile with proper dose titration Regulatory submissions completed in 2024 for obesity treatment [6] Since retatrutide includes GLP-1 receptor activation (similar to semaglutide) plus additional GIP and glucagon receptor effects, the theoretical cagrilintide blend with retatrutide could potentially exceed even the impressive CagriSema results
doi: 10.3390/nu14245316 38
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