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Can antioxidants alone treat melasma

indicates downregulation (decrease)

In contrast, the dose used in our study (10 g/kg/day) likely results in supraphysiological concentrations during the treatment period, which may be necessary to achieve therapeutic effects in a disease state where endogenous irisin production or signaling could be impaired

In HLU, both perform similarly because disuse atrophy involves both mTORC1 suppression (IGF-1 LR3 relevant) and myostatin upregulation (follistatin relevant) in approximately equal measure