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The mechanistic contrast matters clinically: a satiety-hormone agonist and a central stimulant produce different side-effect profiles, different cardiovascular considerations, and different rules about how long a patient can stay on the drug

Research on obese mice suggests that unimolecular poly-pharmacology is an effective means to deal with various mechanisms leading to obesity and further indicates that GCGR activation is the distinguishing factor between single or double agonists and triple agonists of incretin receptors (127)

However, absorption is the critical factor

And remember that you'll enjoy all the benefits, even if you don't enjoy the taste