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Fatigue, tingling, memory changes, or anemia symptoms deserve proper evaluation because many conditions can cause them

Circulating TMAO levels derived from dietary sources are positively correlated with CKD progression, while increased gut microbiota and TMAO derivatives are risk factors for cardiovascular events in patients with CKD (Castillo-Rodriguez et al., 2018

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Multiple randomized controlled trials and real-world studies have shown that adding a GLP-1 agonist to metformin achieves significantly greater weight loss and A1C reduction than metformin alone
